Ulster have been victorious in all competitions so far this season, and will no doubt want to maintain that unbeaten record as the RaboDirect PRO12 breaks for the Autumn Internationals.
In Scotland third placed Glasgow Warriors face a Newport Gwent Dragons team currently residing at the wrong end of the table, and Warriors will be looking for a win to equal their best ever run in the competition.
Elsewhere Munster, who sit just outside the Play-Off zone, travel to Cardiff to take on a Blues team facing their worst run of defeats since the 2004/5 season. Munster need a victory if they are to have any chance of re-entering the top four before the Autumn break.
The two Italian teams are both in action on Saturday, both away from home; Benetton Treviso traveling to the Sportsground in Galway whilst Zebre make their first appearance at Parc y Scarlets. Second placed Scarlets have only lost two games in this campaign whereas their opponents have yet to record a victory, whilst Benetton Treviso sit two places and three points ahead of their hosts, Connacht in the RaboDirect PRO12 table.
The round wraps up on Sunday at the Liberty Stadium when reigning champions Ospreys take on last year’s Play-Off finalists Leinster. Just three points separate the two teams in the table, and should other results go their way, victory could see the Welsh Region take over Leinster’s Play-Off spot in the top four.