Rory Best has been ruled out of contention, having not fully recovered from a rib injury sustained last weekend, while BJ Botha who injured ligaments in his elbow is also unavailable.
Best is replaced at hooker by Nigel Brady, while Declan Fitzpatrick replaces Botha.
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The match will be shown live on Sky Sports 1
Ulster (15-9) Adam D’Arcy; Andrew Trimble, Nevin Spence, Paddy Wallace, Simon Danielli; Ian Humphreys, Ruan Pienaar (1-8) Tom Court, Nigel Brady, Declan Fitzpatrick, Johann Muller (Captain), Dan Tuohy, Stephen Ferris, Willie Faloon, Pedrie Wannenburg
Replacements (16-23): Andi Kyriacou, Bryan Young, Jerry Cronin, Tim Barker, Chris Henry, Paul Marshall, Ian Whitten, David McIlwaine